منابع مشابه
Dopamine Agonists
Dopamine agonists (DA) have been used to treat symptoms of Parkinson’s disease (PD) since the late 1970s (1). These agents were initially introduced to supplement the beneficial effect and possibly reduce the incidence of longterm complications of levodopa. In the last 30 years, methodical investigations of DA have demonstrated therapeutic benefit in all stages of PD both in combination with le...
متن کاملfrom linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar
chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولChanging mountain permafrost from the 1970s to today – comparing two examples from Niwot Ridge, Colorado Front Range, USA
Melting mountain permafrost is reported from alpine areas around the world as a direct consequence of rising air temperatures over the past decades. However, alpine sites that offer suffi cient older data to compare with recent conditions are rare. The study site Niwot Ridge, situated at ~ 3600 m a.s.l. in the Front Range of the Rocky Mountains, Colorado, USA, offers permafrost distribution dat...
متن کاملDopamine-deficient mice are hypersensitive to dopamine receptor agonists.
Dopamine-deficient (DA-/-) mice were created by targeted inactivation of the tyrosine hydroxylase gene in dopaminergic neurons. The locomotor activity response of these mutants to dopamine D1 or D2 receptor agonists and l-3,4-dihydroxyphenylalanine (l-DOPA) was 3- to 13-fold greater than the response elicited from wild-type mice. The enhanced sensitivity of DA-/- mice to agonists was independen...
متن کاملNeuroprotection by dopamine agonists.
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents. Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra of parkinsonian patients emphasize the significance of oxidative stress and free radical formation in the pat...
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ژورنال
عنوان ژورنال: Neuroendocrinology
سال: 2019
ISSN: 0028-3835,1423-0194
DOI: 10.1159/000499470